Inflammatory Cytokines in Heart Failure: Mediators and Markers
نویسندگان
چکیده
منابع مشابه
Inflammatory cytokines in heart failure: mediators and markers.
Evidence from both experimental and clinical trials indicates that inflammatory mediators are of importance in the pathogenesis of chronic heart failure (HF) contributing to cardiac remodeling and peripheral vascular disturbances. Several studies have shown raised levels of inflammatory cytokines such as tumor necrosis factor (TNF)α, interleukin (IL)-1β and IL-6 in HF patients in plasma and cir...
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The cytokine hypothesis presently suggests that an excessive production of pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF) and interleukin 6 (IL6), contributes to the pathogenesis of heart failure. The concept, successfully proved in genetically modified animal models, failed to translate to humans. Recently, accumulation of apparently paradoxical experimental data demons...
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ژورنال
عنوان ژورنال: Cardiology
سال: 2012
ISSN: 1421-9751,0008-6312
DOI: 10.1159/000338166